METHOD OF SYNTHESIS OF PEROXYACETAL LACTONE COMPOUND (VARIANTS) AND LACTONE Russian patent published in 1997 - IPC

FIELD: organic chemistry. SUBSTANCE: product: peroxyacetal lactone compound of the formula (I): where n = 1, 2, 3; m = 0, 1, 2; p = 0, 1; X - group or where R¹ and R² mean hydrogen atom or lower alkyl; or at n above 1 X can be branched and together with one of Y forms 6-membered saturated ring, and other Y can be a lower alkyl and can be bound with the same carbon atom that peroxy-group; R³ and R⁴ together form oxygen atom or each of R³ and R⁴ means hydrogen atom, or one of R³,R⁴ - hydrogen atom and another OR¹ - the group where R¹ - lower alkyl. Compounds were synthesized by oxidation in the presence of one or more metallic catalysts for oxidation of peroxy-compound of the formula (II): where M, n, X, Y and p - as indicated above; R₅ - group -COOH, -C(O)R, -CRR(OH), where R - lower alkyl, hydrogen; R¹ - lower alkyl, or both R¹ together with group -O-C-O to which they bound form cyclic acetal. Invention proposes a method of synthesis of peroxyacetal lactone compound of the formula (I) from compound of the formula (II). The latter is subjected for esterification with the following oxidation of esterification product in the presence of one or some metal-containing oxidation catalysts and its cyclization in solvent with acid catalyst - protonic acid or Lewis acid. Invention proposes also lactone of the formula: . The synthesized compounds were used for synthesis of bioactive compounds, in part, antimalaria agents. EFFECT: improved method of synthesis. 11 cl