FIELD: organic chemistry. SUBSTANCE: taxane derivatives having common formula (I) given in specification are prepared by esterification of protected baccatine III or 10-desacetyl baccatine III by acid having common formula (II) or by its derivative, by removing said protection on side chain and by removing protective functional oxy groups. In formulae (I) and (VII) Ar is phenyl, R is hydrogen atom or acetyl, R1 is benzoyl, or R2-O-CO-, wherein R2 is linear or branched C1-C8-alkyl, R3 is hydrogen atom, C1-C4-alkoxy group or phenyl which may be substituted by one or by two substituents being chosen of C1-C6-alkyl or C1-C6-alkoxy group. Invention also deals with compound having formula (II) given in specification and with intermediate having formula (IV) which is used as intermediate compound by production of compound (I). EFFECT: improved efficiency of the method. 30 cl
Authors
Dates
1998-07-27—Published
1993-10-04—Filed