DERIVATIVE OF $$$-PHENYLISOSERINE, METHOD OF ITS STEREOSELECTIVE SYNTHESIS, THE PARENT COMPOUND FOR ITS SYNTHESIS, METHOD OF SYNTHESIS OF TAXANE AND INTERMEDIATE PRODUCTS Russian patent published in 1998 - IPC

FIELD: organic chemistry. SUBSTANCE: invention relates to a method of stereoselective synthesis of derivative of $$$-phenylisoserine of the formula (I) $$$ by reaction of N-carbonylbenzylimine of the formula (II) Ar-CH= N-CO-R on an optically active protected oxyacetic acid amide of the formula (III) $$$ followed by hydrolysis of synthesized compound. In formulas I-III R means possibly substituted phenyl or $$$ - O; Ar means possibly substituted aryl and $$$ means protective group of functional hydroxy-group; $$$ - direct or branched $$$-alkyl. Compound of the formula (I) is used for synthesis of taxol or taxoter which show antitumor properties. EFFECT: improved method of synthesis. 22 cl