FIELD: chemistry of peptides. SUBSTANCE: product: derivatives of peptides of the general formula (I): $$$ where $$$ - D- or L-9H-thioxantheneglycine, D- or L-9H-xantheneglycine, D-5H-dibenzo-[d,d]-cyclohepteneglycine, L- or D-10,11-dihydro-5H-dibenzo-[a,d]-(cycloheptene-5-yl)-glycine or L- or D-$$$-amino-10,11-dihydro-5H-dibenzo-[a, d]-cycloheptene-5-ace- -tic acid; $$$ - Leu, Arg, Orn, Glu; $$$ - Asp, NMeAsp; $$$ - Ile, Phe; $$$ - Ile, N-MeIle; $$$ - Trp, NForTrp, or their pharmaceutically acceptable salts. The synthesized peptides show antagonistic activity with respect to endothelin and can be used in medicine. EFFECT: improved method of synthesis. 2 cl, 1 tbl
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