METHOD FOR MAKING EXPRESS DIAGNOSIS OF MALIGNANT NEOPLASMS Russian patent published in 1998 - IPC

FIELD: medicine. SUBSTANCE: method involves recording several hundred to several thousand R-R intervals of electrocardiogram (N). Statistics are calculated using standard formulas: R-R interval duration means , mode variance Dr(M²-(Mr)², asymmetry , mode kurtosis and smoothness , n is calculated as the number of R-R intervals satisfying the condition ψ(i) < n(i) ≤ ψ(i+1), where ψ is calculated from formula . Probability p is calculated by applying Markov chains method to describe duration change dynamics of n(i) counted in this way in the direction of their growth or drop. Rhythmogram code is built as sequence of calculated values Mr, Dr, Ar, Er, Sr, p and the nearest patient code YZ and the nearest healthy person code IW are to be determined relative to Euclid's distance between the testee code and the rhythmogram codes available in the sample having groups of healthy and ill persons having oncological diseases. Discrimination function is calculated using formula f(x)= [dist(X,YW)-dist(X,IS)] \ [dist(X,YW)-dist(X,IS)] 1000. If f(X)>10, conclusion is drawn malignant neoplasms are not detected in the examined person. . If f(X)<-10, conclusion is drawn cancer or tumor transformation process is the case. Otherwise if -10 ≤ f(X) ≤ 10, the examined person is to be included into the tumor growth risk group. EFFECT: noninvasive early stage diagnosis method; determined risk groups. 1 dwg