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IPC

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Application

95122192/13, 1995-12-28

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Actual filing date

1995-12-28

(45)

Published

1998-01-20

(72)

Inventor

Karamov Eh.V.Pashkova T.A.Revazova E.S.Baryshnikov A.Ju.Rudneva I.A.Kushch A.A.Gushchina E.A.Kornilaeva G.V.

(73)

Holder

Nauchno-Issledovatel'Skij Institut Virusologii Im.D.I.Ivanovskogo Ramn

STRAIN OF HUMAN TRANSPLANTED CELLS CEM-K SHOWING RESISTANCE TO HIV-INFECTION Russian patent published in 1998 - IPC

Abstract RU 2102477 C1

FIELD: medicinal biotechnology, virology. SUBSTANCE: strain is obtained by the successive passages of lymphoblastoid human cellular line CEM showing sensitivity to HIV-infection in thymusless mice of line BALB/c. Strain shows rise of polyploid (2n = 90), additionally changed chromosomes, enhanced expression of antigen CD 95 and absence of expression of antigen CD 4. Strain can be used as a safe model for investigation of interaction mechanisms of HIV with cell-target and for study of HIV-infection in vitro. EFFECT: cellular strain indicated above. 2 dwg, 3 tbl

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RU 2 102 477 C1

Authors

Karamov Eh.V.

Pashkova T.A.

Revazova E.S.

Baryshnikov A.Ju.

Rudneva I.A.

Kushch A.A.

Gushchina E.A.

Kornilaeva G.V.

Dates

1998-01-20—Published

1995-12-28—Filed

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