FIELD: organic chemistry. SUBSTANCE: products: substituted 3-aminopiperidines of the formula (I) where R1 - phenyl or substituted phenyl, C3-C7-cycloalkoxy, hydroxy, amino--C1-C4-alkylamino-C1-C4-alkyl, phenylhydroxy, naphthyl, thienyl, quinolyl; R2- - phenyl. Reagent 1: aminopiperidine of the formula (II) where R2- - phenyl. Reagent 2: aldehyde of the formula R1--CHO. Reaction conditions: in solvent medium, in the presence of reducing agent. The synthesized compounds were used in medicine as antiinflammatory preparations. EFFECT: improved method of synthesis. 10 cl, 1 tbl
Authors
Dates
1998-02-20—Published
1992-01-14—Filed