FIELD: organic chemistry. SUBSTANCE: invention relates to new derivatives of arylhydroxycycloalkenyl- and arylhydroxyiminocycloalkenylhydroxyureas. The proposed compounds inhibit activity of enzyme 5-lipoxygenase and can be benefit for prophylaxis, treatment or relief of sicknesses course associated with inflammatory processes, for example, gut inflammatory and rheumatic arthritis, allergia and cardiovascular diseases in mammal subject, for example, in human. Invention relates to also pharmaceutical compositions containing these compounds. EFFECT: enhanced effectiveness of compounds proposed.
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Year |
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| DEXTROROTATORY ISOMER OF N-PHENOXYPHENYLCYCLOPENTENE-N-HYDROXY- -UREA AND PHARMACEUTICAL COMPOSITION INHIBITING 5-LIPOXYGENASE ACTIVITY |
1994 |
- Akijosi Kavai
- Rodni V.Stivens
|
RU2125987C1 |
| METHOD OF PREPARING N-HYDROXYUREA, N-HYDROXYUREA DERIVATIVES AND METHOD OF INHIBITING LIPOXYGENASE IN MAMMALS |
1991 |
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| COMPOUND, PHARMACEUTICAL COMPOSITION, METHOD OF TREATMENT AND PROPHYLAXIS OF ENDOMETRITIS, INTERMEDIATE COMPOUND |
1996 |
- Kimberli O.Kameron
- Pol' A.Dasilva Zhardine
- Robert L.Rozati
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RU2130454C1 |
| N-HYDROXYLUREAS AS ANTI-INFLAMMATORY AGENTS |
1995 |
- Ando Akemi
- Stivens Rodni V.
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RU2152935C2 |
| BENZOPYRANE AND BENZOCONDENSED COMPOUNDS, INTERMEDIATE COMPOUNDS, PHARMACEUTICAL COMPOSITION AND A METHOD OF INHIBITION |
1995 |
- Mark A.Dombroski
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RU2128655C1 |
| 3R,4S 3-[4-(4-FLUOROPHENYL)-4-HYDROXYPIPERIDIN-1- YL)CHROHAN-4,7-DIOL, OPTICAL ISOMERS THEREOF AND PHARMACEUTICAL COMPOSITION BASED THEREON, AND METHOD OF MEDICAL TREATMENT |
1994 |
- Todd V.Batler
- Bertrand L.Chenard
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| BENZOFUSED COMPOUNDS, PHARMACEUTICAL COMPOSITION BASED ON THEREOF, METHOD OF THEIR SYNTHESIS AND A METHOD OF SYNTHESIS OF AN INTERMEDIATE COMPOUND |
1992 |
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| DERIVATIVES OF OXAZOLE OR THEIR PHARMACEUTICALLY ACCEPTABLE CATION SALTS OR ACID ADDITIVE SALTS |
1992 |
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| INTERMEDIATE PRODUCTS FOR PREPARATION OF 1-BENZYL-4-[(5,6-DIMETHOXY-1-INDANONE 2-YL)METHYLPIPERIDINE, METHOD OF PREPARATION THEREOF AND METHOD OF PREPARING 1- BENZYL-4-[(5,6-DIMETHOXY-1-INDANONE)-2-YL)METHYLPIPERIDINE AND USE THEREOF |
1996 |
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| COMPOUNDS AND COMPOSITIONS USED FOR TREATMENT OF NTRK-RELATED DISORDERS |
2016 |
- Wenglowsky Steven Mark
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