POLYSACCHARIDE FROM NEISSERIA MENINGITIDES CONTAINING MODIFIED GROUP B, CONJUGATED ANTIGEN, VACCINE AGAINST MENINGITIS GROUP B AND A METHOD OF INDUCTION OF ANTIBODY RESPONSE TO MENINGITIS OF GROUP B Russian patent published in 1998 - IPC

FIELD: biotechnology, microbiology. SUBSTANCE: polysaccharide of Neisseria MENINGITIDES group B modified by substitution of N-acetyl groups of sialic acids residue with C₄-C₈--acyl groups exhibits enhanced immune response. Induction of antibodies that show cross-over interaction with nonmodified meningococcal capsule polysaccharide group B and other tissue cells of simple epitope is decreased to minimal values. Conjugation of modified polysaccharide with physiologically acceptable protein, for example, tetanus anatoxin, induces production of specific protective antibodies at nonsignificant levels of GVMP - cross-over reacting antibodies. This provides protection against infections caused by meningococcus of group B. EFFECT: improved method of induction. 18 cl, 5 tbl, 1 ex