FIELD: medicine, pharmaceutics.
SUBSTANCE: group of inventions refers to medicine, namely biopharmaceutics, and may be used for making vaccines. For this purpose, the vaccine contains: native outer membrane vesicles (NOMV) prepared of at least two meningococcal strains which are genetically modified for a wide safety spectrum, wherein the native outer membrane vesicles contain various antigen sets, wherein the various antigen sets contain one or more PorA proteins, one or more LOS and one or more conservative outer membrane proteins; wherein the genetically modified stains are modified for providing higher safety by lpxLl, synX and lgtA gene inactivation; and wherein at least one genetically modified stain expresses at least two various protein subtypes or PorA epitope subtypes. There are also presented a method for stimulating an immune response to meningococcosis involving the introduction of the vaccine composition under the present invention.
EFFECT: group of inventions provides protective immunity against meningococcosis, preferentially subtype B meningococcosis.
49 cl, 11 ex, 21 dwg
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