STABILIZED PHARMACEUTICAL COMPOSITION AND METHOD FOR ITS STABILIZATION Russian patent published in 1998 - IPC

Abstract RU 2107500 C1

FIELD: pharmaceutics; production of stabilized antitumor pharmaceuticals. SUBSTANCE: composition comprises paclitaxel, or camptotecyn, or their derivatives, ethanol as a solvent, and alkylene oxide condensation product such as polyoxyethylated castor oil is treated with acid or brought into contact with aluminium oxide to decrease concentration of carboxylate anions in solvent. EFFECT: extended storage life thanks to low concentration of carboxylate anions in solvent; reduced quality of by-products formed by decomposition. 15 cl, 5 tbl

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RU 2 107 500 C1

Authors

Shrirkhehm Narakhari Agkharkar[Us]

Judej S.Gougejt[In]

Tomas Kehvehnehk[Do]

Dates

1998-03-27—Published

1994-09-28—Filed