CRYSTALLINE ETOPOZIDE 4'-PHOSPHATE DIETHANOLSOLVATE AND A METHOD OF ITS SYNTHESIS Russian patent published in 1995 - IPC

Abstract RU 2042686 C1

FIELD: organic chemistry. SUBSTANCE: product: crystalline etopozide 4′-phosphate diethanolsolvate of the formula (I) (image), m. p. is 160-172 C, empirical formula is C₂₉H₃₃O₁₆P·2C₂H₆O., yield is 91% Reagent 1: 4′-phosphate etopozide. Reagent 2: absolute ethanol or methanol, at boiling with reflux condenser. Reagent 3: (when ethanol is used) water. Synthesized compound were used as an antitumor preparation. EFFECT: improved method of synthesis. 5 cl, 2 dwg, 1 tbl

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RU 2 042 686 C1

Authors

Denis Favrou[Ca]

Dates

1995-08-27—Published

1992-09-30—Filed