FIELD: medical engineering. SUBSTANCE: device has inverse layer impermeable for biologically active substance, the layer having adhesive properties when coming in engagement with intermediate (holding) layer having 40-90 % by mass of polymer material, 0.1-20 % by mass of physostigmine base or one of its pharmacologically permissible salts and also an intermediate covering (holding) layer. Base of uncoverable protection layer has polymer material on acrylate and/or metacrylate substratum and plasticizer having hydroxyl groups in the amount of 0.1-40% by mass with hydrophily coefficient being equal to 1.1-12.0 in the intermediate (holding) layer. EFFECT: enhanced effectiveness in introducing physostigmine through skin. 8 cl, 5 tbl
