MICRORESERVOIR SYSTEM BASED ON POLYSILOXANES AND AMBIPHILIC SOLVENTS Russian patent published in 2005 - IPC

FIELD: polymers, medicine.

SUBSTANCE: transdermal therapeutic system comprises externally layer impermeable for active substance, polymeric layer with microreservoirs dispersed in it and containing dissolved active substance and protective layer removing before using. Polymeric part of polymeric layer consists of polydimethylsiloxanes. Ambiphilic solvent for active substance represents dipolar organic solvent possessing limited mixing capacity with polydimethylsiloxanes. Indicated ambiphilic solvent is mixed with water in the mass ratio 1:3. Active substances useful for transdermal applying are characterized by mean polarity. In applying on skin transdermal systems are characterized by satisfied release of active substance and retaining relatively constant thermodynamic activity.

EFFECT: valuable properties of system.

9 cl, 4 dwg, 4 ex