METHOD OF PREPARING THE COMBINED MEDICINAL PREPARATION IN SOLID GELATINOUS CAPSULES Russian patent published in 1998 - IPC

FIELD: chemical-pharmaceutical industry. SUBSTANCE: invention relates to preparing the combined drug eliciting analgetic, antipyretic and antiinflammatory effects in the form of solid gelatinous capsules. Method of preparing the stable and nontoxic medicinal form of combined preparation "Citropar" containing acetylsalicylic acid, paracetamol, caffeine and citric acid involves the use the corresponding powders. Powders are sieved, mixed with additional substances and dosed into solid gelatinous capsules. Talc (2.5-3.0%), polyvinylpyrrolidone and aerosil (0.65-0.7%) are used as additional substances. To decrease toxicity of preparation paracetamol at amount 33-41% is added instead of phenacetin. EFFECT: improved technology of preparing, improved quality, bioavailability and stability of preparation.