DEXTROROTATORY ISOMER OF 6-(5-CHLORO-2-PYRIDYL)-(4-METHYL-1- -PIPERAZINYL)-5-CARBONYLOXY-7-OXO-6,7-DIHYDRO-5H-PYRROLO- -[3,4-B]-PYRAZINE AND ITS PHARMACEUTICALLY ACCEPTABLE ACID-ADDITIVE SALT, METHOD OF THEIR SYNTHESIS AND PHARMACEUTICAL COMPOSITION BASED ON THEREOF Russian patent published in 1998 - IPC

Abstract RU 2110519 C1

FIELD: organic chemistry. SUBSTANCE: product: dextrorotatory isomer of 6-(5- -chloro-2-pyridyl)-(4-methyl-1-piperazinyl)-5-carbonyloxy-7- -oxo-6,7-dihydro-5H-pyrrolo-[3,4-b] -pyrazine and its pharmaceutically acceptable acid-additive salt. Compound is synthesized by splitting the corresponding racemate using D-(+)-O,O'-dibenzoyltartaric acid in organic solvent. Pharmaceutical composition has an active substance indicated above at effective amount and pharmaceutically acceptable additions. Compound shows tranquilizing, hypnotic and anticonvulsant properties and can be used in medicine and pharmacy. EFFECT: improved method of synthesis, enhanced effectiveness. 3 cl, 1 tbl

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RU 2 110 519 C1

Authors

Klod Kotrel'[Fr]

Zherar Russel'[Fr]

Dates

1998-05-10—Published

1992-01-16—Filed