ACID ANHYDRIDES, METHOD OF PREPARATION THEREOF, METHODS OF PREPARATION THEREOF, METHODS OF PREPARATION OF TAXOL OR TAXOTERAN Russian patent published in 1998 - IPC

FIELD: medicine. SUBSTANCE: present invention describes novel anhydrides of general formula: $$$ wherein Ar is aryl and/or $$$ is $$$ or $$$; $$$ is hydrogen of atom and $$$ is protecting group for hydroxyl function; or $$$ is $$$ and $$$ and $$$ together form saturated 5-or 6-membered heterocycle. Present invention also describes of preparation of said compounds and use thereof for preparation of taxane derivatives of general formula: $$$ wherein R is H; $$$ is $$$ or $$$. Said novel compounds have antitumor properties. EFFECT: more efficient preparation method. 10 cl