FIELD: medicine, pharmacy. SUBSTANCE: method involves extraction of ground vegetable raw using plants of family Dioscoreaceae, Plantaginaceae and Solanaceae with water. Aqueous extract is centrifuged, concentrated, precipitated with 96% ethyl alcohol in the presence of sodium chloride. Repeated precipitation of obtained deposit is carried out with saline or acid agent followed by treatment of isolated acid crude peptidoglycane with alkali solution or alkaline metal salt saturated solution. Product is purified by gel-penetrating chromatography and drying. Substance obtained by this method is a water-soluble acid peptidoglycane with molecular mass 1200-40000 kDa and mass ratio of glucose to uronic acids = 1: (2-4). Pharmaceutical composition comprises active substance and carrier. Invention allows to obtain the novel vegetable substance from available raw that exhibits the strong expressed immunostimulating, antiviral and antibacterial activity. EFFECT: improved method of preparing, valuable medicinal properties of substance. 8 cl, 12 tbl, 13 ex
| Title | Year | Author | Number |
|---|---|---|---|
| METHOD OF OBTAINING SUBSTANCE, POSSESSING ANTIMICROBIAL, ANTIVIRAL AND IMMUNOSTIMULATING ACTIVITY, IN PARTICULAR, WITH RESPECT TO DENDRITE CELLS, SUBSTANCE, THEREOF OBTAINED, AND BASED ON IT PHARMACEUTICAL COMPOSITION | 2013 |
|
RU2563818C2 |
| CONJUGATE FOR IMMUNISATION AND VACCINATION AND METHOD FOR IMPROVING IMMUNOGENICITY | 2008 |
|
RU2378015C2 |
| COMPOSITION FOR AMPLIFICATION OF TRANSGENE EXPRESSION IN EUCARIOTIC CELLS, AND METHOD FOR INCREASING GENERATION OF TARGET PROTEIN CODED WITH TRANSGENE | 2013 |
|
RU2546249C2 |
| BROAD-SPECTRUM M2 PROTEIN ECTODOMAIN AVIAN INFLUENZA TYPE A VACCINE | 2014 |
|
RU2571944C1 |
| RECOMBINANT TRIVALENT INFLUENZA VACCINE | 2012 |
|
RU2485973C1 |
| POLYMER FRAGMENT OF PEPTIDOGLICAN OF GRAM-NEGATIVE BACTERIA CELL WALL, METHOD OF ITS OBTAINING AND ITS APPLICATION AS IMMUNOSTIMULATOR | 2006 |
|
RU2412197C2 |
| METHOD FOR PREPARING PHARMACOLOGICALLY ACCEPTABLE MIXTURE OF SUBSTANCES CONTAINING LOW-MOLECULAR INGREDIENTS OF CELL WALL PEPTIDOGLYCANE OF GRAM-NEGATIVE BACTERIA AND POSSESSING IMMUNOSTIMULATORY ACTIVITY | 2008 |
|
RU2478644C2 |
| PHARMACEUTICAL COMPOSITION WITH CYTOKINE AND IMMUNOMODULATING EFFECTS | 2002 |
|
RU2222345C2 |
| COMPOSITION COMPRISING LOW-MOLECULAR FRAGMENTS OF PEPTIDOGLICANE OF GRAM-NEGATIVE BACTERIA FOR PREVENTING OR TREATING OF HUMAN DISEASES | 2009 |
|
RU2441906C2 |
| EZRIN DERIVATIVES PEPTIDES AND PHARMACEUTICAL COMPOSITIONS BASED THEREON | 2016 |
|
RU2694906C2 |
