FIELD: medicine, immunology. SUBSTANCE: rabbits are immunized with specific antigen - preparation polymer-transthyretin containing 15-25 wt.-% polymeric forms in mixture with Freund's adjuvant. Injection dose has preparation at amount 0.6-1.2 mg. Injection is made by two-fold intracutaneous administration at 14 days interval. Preparation polymer-transthyretin is prepared by treatment of transthyretin solution (protein concentration is 3-6 mg/ml) with glutaric aldehyde at final concentration 2-8 mmole/l at pH 7.0-7.4. Method is used for immunodiagnosticum production. EFFECT: enhanced immunogenicity of human transthyretin, decreased immunization time of animals.
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