FIELD: organic chemistry. SUBSTANCE: invention relates to derivatives of galanthamine of the general formula (II) 
where R1 means hydrogen, (C1-C12)-alkylcarbonyl, (C1-C12)-alkoxycarbonyl, mono-(C1-C12)-alkylaminocarbonyl or di-(C1-C12)-alkylaminocarbonyl; R2 means mono-(C1-C180-alkylaminocarbonyloxy- or di-(C1-C8)-alkylaminocarbonyloxy-group; R3 means hydrogen or halogen, or their pharmaceutically acceptable acid-additive salts. Compounds of the general formula (II) are benefit as inhibitors of acetylcholine esterase. Invention proposes also pharmaceutical composition based on indicated derivatives. EFFECT: improved method of synthesis, enhanced effectiveness of derivatives and composition. 8 cl, 3 tbl, 18 ex
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