FIELD: biotechnology. SUBSTANCE: at the first stage of a method producer culture is grown under optimal conditions. Then mycelium is separated from cultural fluid and tylosin antibiotics are sorbed on acid cation-exchange resin. Elution from sorbent is carried out by diluted an aqueous ammonia solutions followed by drying the end product. Method is used for crystalline tylosin preparing. EFFECT: improved purity of tylosin, increased yield.
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Authors
Dates
1998-06-27—Published
1997-07-23—Filed