FIELD: biological industry. SUBSTANCE: 2-saccharinylmethylaryl carboxylates are prepared by reacting halomethylsaccharin with suitable acid or salt thereof. Second method comprises reacting saccharin with alkylcarboxylic acid chloromethyl ester to obtain 4-isopropyl-6-methoxy-2-saccharinylmethyl-2,6- dichloro-3-carboxymethylaminosulfonyl benzoate, yield is 45% and m.p. is 204-206 C. Compounds inhibit activity of proteolytic enzymes. EFFECT: improved properties of proteolytic enzymes. 16 cl, 15 tbl
| Title |
Year |
Author |
Number |
| SACCHARIN DERIVATIVE OR ITS PHARMACEUTICALLY ACCEPTABLE SALT, PHARMACEUTICAL COMPOSITION FOR INHIBITION OF PROTEOLYTIC ENZYMES IN TREATMENT OF PATIENTS WITH DEGENERATIVE SICKNESSES |
1994 |
- Dennis Dzhon Lasta
- Dzhejms Govard Akerman
- Al'Bert Dzhozef Mura
- Randzhit Chimanlal Desaj
|
RU2126798C1 |
| 2-SACCHARINYLMETHYLHETEROCYCLIC CARBOXYLATES OR THEIR BASIC ACID-ADDITIVE SALTS OR ACID BASIC-ADDITIVE SALTS AND PHARMACEUTICAL COMPOSITION INHIBITING ACTIVITY OF PROTEOLYTIC ENZYMES |
1992 |
- Richard Pol' Danlehp[Us]
- Denniz Dzhon Khlasta[Us]
- Randzhit Chimanlal Desaj[In]
- Li Gamil'Ton Lehjtimer[Us]
- Chakrapani Sabraman'Jam[In]
- Dzhon Dzhozef Kurt[Us]
- Mehlkol'M Rajs Bell[Us]
- Virendra K'Jumar[Us]
|
RU2078081C1 |
| DERIVATIVE OF SACCHARINE OR ITS PHARMACEUTICALLY ACCEPTABLE SALT, METHOD FOR ITS PRODUCTION, DERIVATIVES OF SACCHARINE WHICH INHIBITS ACTIVITY OF PROTEOLYTIC FERMENTS, PHARMACEUTICAL COMPOSITION HAVING ACTIVITY AS INHIBITOR OF PROTEOLYTIC FERMENT |
1992 |
- Denniz Dzhon Khlasta[Us]
- Dzhejms Khovard Akerman[Us]
- Al'Bert Dzhozef M'Jura[Us]
|
RU2107685C1 |
| DERIVATIVE OF 2-SUBSTITUTED SACCHARIN AND PHARMACEUTICAL COMPOSITION SHOWING INHIBITORY ACTIVITY WITH RESPECT TO ELASTASE |
1992 |
- Richard Pol' Danlehp[Us]
- Nejl Uorren Boaz Al'Bert Dzhozef M'Jura[Us]
- Denniz Dzhon Khlasta[Us]
- Randzhit Chimanlal Desaj[In]
- Chakrapani Sabraman'Jam[In]
- Li Gamil'Ton Lehjtimer[Us]
- Ehrik Piehtt Lodzh[Us]
|
RU2101281C1 |
| 2-SACCHARINYLMETHYL(ARYL OR ARYLHYDROXY) ACETATES, OR THEIR SALTS FORMED BY ADDITION OF ACIDS TO THESE BASIC COMPOUNDS, OR THEIR SALTS FORMED BY BASES ADDITION TO THESE ACID COMPOUNDS, AND PHARMACEUTICAL COMPOSITION INHIBITING ACTIVITY OF PROTEOLYTIC ENZYMES |
1992 |
- Li Gamil'Ton Lehjtimer[Us]
- Richard Pol' Danlehp[Us]
|
RU2081871C1 |
| SACCHARIN DERIVATIVES OR THEIR PHARMACEUTICALLY ACCEPTABLE ACID OR BASE ADDITIVE SALT, PHARMACEUTICAL COMPOSITION EXHIBITING ACTIVITY OF ELASTASE INHIBITOR |
1992 |
- Richard Pol' Danlehp
- Al'Bert Dzhozef M'Jura
- Denniz Dzhon Khlasta
- Randzhit Chimanlal Desaj
- Li Gamil'Ton Lehjtimer
- Chakrapani Sabraman'Jam
|
RU2114835C1 |
| 2-SACCHARINYLMETHYL- OR 4,5,6,7-TETRAHYDRO-2-SACCHARINYLMETHYL PHOSPHATES, -PHOSPHONATES OR -PHOSPHINATES AND PHARMACEUTICAL COMPOSITION BASED ON THEREOF |
1992 |
- Randzhit Chimanlal Desaj[In]
- Dzhon Dzhozef Kurt[Us]
- Denniz Dzhon Khlasta[Us]
- Chakrapani Subraman'Jam[In]
|
RU2091377C1 |
| 1,2,4-OXADIAZOLYLPHENOXYALKYLISOXAZOLES AND COMPOSITION AGAINST PICORNOVIRUSES |
1993 |
- Gaj Dominik Diana
- Teodor Dzhon Nitts
|
RU2114112C1 |
| THIOXANTHENONE COMPOUNDS AND PHARMACEUTICAL COMPOSITIONS SHOWING ANTITUMOR ACTIVITY |
1994 |
- Mark Filip Ventlend
- Robert Bruno Perni
- Dzhozef Vill'Jam Gajls
|
RU2138495C1 |
| NOVEL DERIVATIVES OF 2,6-DIAMINOPYRIDIN-3-ONE |
2005 |
- Bartkovitts Dejvid Dzhozef
- Chu Sin'Tszi
- Lovi Allen Dzhon
- Vovkulich Piter Majkl
|
RU2385866C2 |
