DERIVATIVE OF SACCHARINE OR ITS PHARMACEUTICALLY ACCEPTABLE SALT, METHOD FOR ITS PRODUCTION, DERIVATIVES OF SACCHARINE WHICH INHIBITS ACTIVITY OF PROTEOLYTIC FERMENTS, PHARMACEUTICAL COMPOSITION HAVING ACTIVITY AS INHIBITOR OF PROTEOLYTIC FERMENT Russian patent published in 1998 - IPC

FIELD: chemistry of heterocyclic compounds; production of pharmaceutical compositions. SUBSTANCE: derivative of saccharine has formula where R₁ is H or lower alkyl; R₂ is hydrogen, lower alkoxy group, hydroxyl, hydroxy (lower)alkoxy group, phenyl (lower)alkoxycarbonyl (lower)alkoxy group; X is hydrogen, lower alkyl, phenyl, phenyl (lower)alkyl, phenyl carbonyl, lower alkanoyl, lower alkoxycarbonyl, B=N, B=N-(lower)alkyl, phenyloxy group where B=N is 1-piperidinyl or 4-morpholinyl; Y is or -N=C(Z″)-N(Z″)- where m=1,2,3 or 4; R, R′, R″, Z′ and Z″ have value mentioned above. Method for production of compound having formula I and pharmaceutical composition on its base are also proposed. EFFECT: improved quality of desired product, improved efficiency of the method. 10 cl, 4 tbl