FIELD: organic chemistry. SUBSTANCE: product: new 4-R1-R2-R3-2-saccharinylmethyl-, 4-R4-4-R5-6-R6-4,5,6,7-tetrahydro-2-saccharinylmethyl- and 4,7-C-4,5,6,7-tetrahydro-2-saccharinylmethylphosphates, -phosphonates and -phosphinates of the formulas (I), (II) and (IIA), respectively, and compositions containing thereof. Invention relates to also methods of synthesis of the indicated compounds by reaction of the corresponding 2-halogenmethylsaccharins with phosphate, phosphonate or phosphinic acid of the formula (III) in the presence of acid acceptor. EFFECT: improved method of synthesis. 2 cl, 5 dwg, 8 tbl
| Title |
Year |
Author |
Number |
| 2-SACCHARINYLMETHYL(ARYL OR ARYLHYDROXY) ACETATES, OR THEIR SALTS FORMED BY ADDITION OF ACIDS TO THESE BASIC COMPOUNDS, OR THEIR SALTS FORMED BY BASES ADDITION TO THESE ACID COMPOUNDS, AND PHARMACEUTICAL COMPOSITION INHIBITING ACTIVITY OF PROTEOLYTIC ENZYMES |
1992 |
- Li Gamil'Ton Lehjtimer[Us]
- Richard Pol' Danlehp[Us]
|
RU2081871C1 |
| 2-SACCHARINYLMETHYLHETEROCYCLIC CARBOXYLATES OR THEIR BASIC ACID-ADDITIVE SALTS OR ACID BASIC-ADDITIVE SALTS AND PHARMACEUTICAL COMPOSITION INHIBITING ACTIVITY OF PROTEOLYTIC ENZYMES |
1992 |
- Richard Pol' Danlehp[Us]
- Denniz Dzhon Khlasta[Us]
- Randzhit Chimanlal Desaj[In]
- Li Gamil'Ton Lehjtimer[Us]
- Chakrapani Sabraman'Jam[In]
- Dzhon Dzhozef Kurt[Us]
- Mehlkol'M Rajs Bell[Us]
- Virendra K'Jumar[Us]
|
RU2078081C1 |
| DERIVATIVE OF 2-SUBSTITUTED SACCHARIN AND PHARMACEUTICAL COMPOSITION SHOWING INHIBITORY ACTIVITY WITH RESPECT TO ELASTASE |
1992 |
- Richard Pol' Danlehp[Us]
- Nejl Uorren Boaz Al'Bert Dzhozef M'Jura[Us]
- Denniz Dzhon Khlasta[Us]
- Randzhit Chimanlal Desaj[In]
- Chakrapani Sabraman'Jam[In]
- Li Gamil'Ton Lehjtimer[Us]
- Ehrik Piehtt Lodzh[Us]
|
RU2101281C1 |
| SACCHARIN DERIVATIVES OR THEIR PHARMACEUTICALLY ACCEPTABLE ACID OR BASE ADDITIVE SALT, PHARMACEUTICAL COMPOSITION EXHIBITING ACTIVITY OF ELASTASE INHIBITOR |
1992 |
- Richard Pol' Danlehp
- Al'Bert Dzhozef M'Jura
- Denniz Dzhon Khlasta
- Randzhit Chimanlal Desaj
- Li Gamil'Ton Lehjtimer
- Chakrapani Sabraman'Jam
|
RU2114835C1 |
| 3-ARYLCARBONYL-1-AMINOALKYL-1H-INDOLES |
1992 |
- S'Juzan Dzhin Vord[Us]
- Malkol'M Rajs Bell[Us]
|
RU2073670C1 |
| METHOD OF NUCLEOSIDE LINKAGE BY 3'--5'-INTERNUCLEOTIDE SILYL UNIT |
1991 |
- Uehjs Aleksandr Ljudvik[Il]
- Sakha Ashiz K'Jumar[In]
- Khaushir Frederik German[Us]
|
RU2079508C1 |
| 2-SACCHARINYLMETHYLARYL CARBOXYLATES, METHOD OF PREPARING THEREOF (VARIANTS), AND COMPOSITION INHIBITING ACTIVITY OF PROTEOLYTIC ENZYME |
1991 |
- Richard Pol' Danlehp
- Nejl Uorren Bouz
- Ehbert Dzhozef M'Jure
- Vajrindra Kumar
- Chakrapani Subramaniam
- Ranzhit Chimanlal Desai
- Dehnniz Dzhon Lasta
- Manokhar Tukram Sehjndehjn
- Mehlkol'M Rajs Behll
- Dzhon Dzhozef Kurt
|
RU2114843C1 |
| MEDICINAL SUBSTANCE PARTICLES, METHOD OF THEIR PREPARING, STABLE DISPERSION, AGENT CONTAINING MEDICINAL SUBSTANCE AS PARTICLES |
1992 |
- Gari Liversidzh[Us]
- Kennet Kandi[Us]
- Dzhon Bishop[Us]
- Dehvid Zhekaj[Us]
|
RU2066553C1 |
| DERIVATIVE OF SACCHARINE OR ITS PHARMACEUTICALLY ACCEPTABLE SALT, METHOD FOR ITS PRODUCTION, DERIVATIVES OF SACCHARINE WHICH INHIBITS ACTIVITY OF PROTEOLYTIC FERMENTS, PHARMACEUTICAL COMPOSITION HAVING ACTIVITY AS INHIBITOR OF PROTEOLYTIC FERMENT |
1992 |
- Denniz Dzhon Khlasta[Us]
- Dzhejms Khovard Akerman[Us]
- Al'Bert Dzhozef M'Jura[Us]
|
RU2107685C1 |
| SACCHARIN DERIVATIVE OR ITS PHARMACEUTICALLY ACCEPTABLE SALT, PHARMACEUTICAL COMPOSITION FOR INHIBITION OF PROTEOLYTIC ENZYMES IN TREATMENT OF PATIENTS WITH DEGENERATIVE SICKNESSES |
1994 |
- Dennis Dzhon Lasta
- Dzhejms Govard Akerman
- Al'Bert Dzhozef Mura
- Randzhit Chimanlal Desaj
|
RU2126798C1 |
