FIELD: chemistry of heterocyclic compounds. SUBSTANCE: product: 2-saccharinylmethyl(aryl or arylhydroxy) acetates of the formula (I) 
where: m = 0 or 1; n = 0 or 1 and the sum m + n = 0 or 1; R1 - H or lower alkyl; R2 - H or lower alkyl; R3 - phenyl or phenyl substituted with 1-3 similar or different halogens; R4 - H, lower alkyl or lower alkoxy-group; R5- - H or 1-2 substituents at any of 5-, 6- or 7-position taken from lower alkyl, lower alkoxy-group, hydroxy(lower) alkyl, hydroxy(lower)alkoxy-group or their salts, and also pharmaceutical composition based on these compounds inhibiting activity of proteolytic enzymes. EFFECT: improved method of synthesis. 13 cl, 12 tbl
| Title | Year | Author | Number |
|---|---|---|---|
| 2-SACCHARINYLMETHYLHETEROCYCLIC CARBOXYLATES OR THEIR BASIC ACID-ADDITIVE SALTS OR ACID BASIC-ADDITIVE SALTS AND PHARMACEUTICAL COMPOSITION INHIBITING ACTIVITY OF PROTEOLYTIC ENZYMES | 1992 |
|
RU2078081C1 |
| 2-SACCHARINYLMETHYL- OR 4,5,6,7-TETRAHYDRO-2-SACCHARINYLMETHYL PHOSPHATES, -PHOSPHONATES OR -PHOSPHINATES AND PHARMACEUTICAL COMPOSITION BASED ON THEREOF | 1992 |
|
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| DERIVATIVE OF 2-SUBSTITUTED SACCHARIN AND PHARMACEUTICAL COMPOSITION SHOWING INHIBITORY ACTIVITY WITH RESPECT TO ELASTASE | 1992 |
|
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| SACCHARIN DERIVATIVES OR THEIR PHARMACEUTICALLY ACCEPTABLE ACID OR BASE ADDITIVE SALT, PHARMACEUTICAL COMPOSITION EXHIBITING ACTIVITY OF ELASTASE INHIBITOR | 1992 |
|
RU2114835C1 |
| 2-SACCHARINYLMETHYLARYL CARBOXYLATES, METHOD OF PREPARING THEREOF (VARIANTS), AND COMPOSITION INHIBITING ACTIVITY OF PROTEOLYTIC ENZYME | 1991 |
|
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| 3-ARYLCARBONYL-1-AMINOALKYL-1H-INDOLES | 1992 |
|
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| METHOD OF NUCLEOSIDE LINKAGE BY 3'--5'-INTERNUCLEOTIDE SILYL UNIT | 1991 |
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RU2079508C1 |
| SACCHARIN DERIVATIVE OR ITS PHARMACEUTICALLY ACCEPTABLE SALT, PHARMACEUTICAL COMPOSITION FOR INHIBITION OF PROTEOLYTIC ENZYMES IN TREATMENT OF PATIENTS WITH DEGENERATIVE SICKNESSES | 1994 |
|
RU2126798C1 |
| DERIVATIVE OF SACCHARINE OR ITS PHARMACEUTICALLY ACCEPTABLE SALT, METHOD FOR ITS PRODUCTION, DERIVATIVES OF SACCHARINE WHICH INHIBITS ACTIVITY OF PROTEOLYTIC FERMENTS, PHARMACEUTICAL COMPOSITION HAVING ACTIVITY AS INHIBITOR OF PROTEOLYTIC FERMENT | 1992 |
|
RU2107685C1 |
| CONTRAST RADIOGRAPHIC COMPOSITION, METHOD FOR VISUALIZING DURING TOMOGRAPHIC EXPERIMENTAL EXAMINATIONS AND METHOD FOR PREPARING SAID CONTRAST RADIOGRAPHIC COMPOSITION | 1992 |
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RU2074002C1 |
