FIELD: organic chemistry, medicine, pharmacy. SUBSTANCE: invention relates to new compounds of the formula (I) 
where B and E are taken independently from CH or N; R4 - hydrogen, halogen atom, hydroxy-group; G means compounds of the formula (II) (a, b, c) 
, their optic and geometric isomers and nontoxic pharmaceutically acceptable acid-additive salts. Also, invention describes a pharmaceutical composition and a method of treatment using compound of the formula (I) that shows an estrogen-antagonistic/agonistic activity. EFFECT: improved method of treatment, enhanced effectiveness of composition. 21 cl, 14 ex
| Title |
Year |
Author |
Number |
| METHOD OF SYNTHESIS OF CIS-1-{2-[4-(6-METHOXY-2-PHENYL-1,2,3,4-TETRAHYDRONAPHTHALENE-1-YL)-PHENOXY]ETHYL}PYRROLIDINE AND INTERMEDIATE COMPOUNDS |
2000 |
|
RU2195445C2 |
| BENZOFUSED COMPOUNDS, PHARMACEUTICAL COMPOSITION BASED ON THEREOF, METHOD OF THEIR SYNTHESIS AND A METHOD OF SYNTHESIS OF AN INTERMEDIATE COMPOUND |
1992 |
|
RU2114110C1 |
| BENZOPYRANE AND BENZOCONDENSED COMPOUNDS, INTERMEDIATE COMPOUNDS, PHARMACEUTICAL COMPOSITION AND A METHOD OF INHIBITION |
1995 |
- Mark A.Dombroski
- Kevin Kokh
- Ehntoni Daniehl' Piskop'O
|
RU2128655C1 |
| (-)-CIS-6(S)-PHENYL-5(R)-[4-(2-PYRROLIDINE-1-YLETHOXY)PHENYL]- -5,6,7,8-TETRAHYDRONAPHTHALINE-2-OL D-TARTRATE, METHOD OF ITS SYNTHESIS, METHOD OF PROPHYLAXIS OF STATES INFLUENCING WITH TO EFFECT OF ESTROGEN AGONISTS, PHARMACEUTICAL COMPOSITION |
1996 |
- Charl'Z K. Chiu
- Morgan Mel'Tts
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RU2162465C2 |
| ARYLHYDROXYCYCLOALKENYL- AND ARYLHYDROXYIMINOCYCLOALKENYLHYDROXYUREAS AND PHARMACEUTICAL COMPOSITION INHIBITING ACTIVITY OF 5-LIPOXYGENASE |
1995 |
- Akiesi Kavai
- Makoto Kavai
- Rodni V.Stivens
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RU2119479C1 |
| DERIVATIVES OF OXAZOLE OR THEIR PHARMACEUTICALLY ACCEPTABLE CATION SALTS OR ACID ADDITIVE SALTS |
1992 |
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RU2079497C1 |
| IMIDAZOLE DERIVATIVES OR THEIR PHARMACEUTICALLY ACCEPTABLE SALTS |
1994 |
- Rodni V.Stivens
- Takasi Mano
- Kazuo Ando
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RU2126004C1 |
| HETEROCYCLIC COMPOUND, PHARMACEUTICAL COMPOSITION AND METHOD OF INHIBITION OF 5-LIPOXYGENASE ACTIVITY |
1995 |
- Rodni V. Stivens
- Takasi Mano
- Kazunari Nakao
- Josijuki Okumura
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RU2136666C1 |
| HYDROGENATED NITROGEN-CONTAINING HETEROCYCLIC COMPOUNDS, DERIVATIVES OF PYPERIDINE, PHARMACEUTICAL COMPOSITION AND METHOD FOR SUPPRESSING ACTIVITY OF P COMPOUND IN ORGANISM |
1991 |
- Manodzh S.Desaj[In]
- Terri Dzh.Rosen[Us]
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RU2105758C1 |
| STIMULATING AGENTS OF GROWTH HORMONE SECRETION |
1996 |
- Filip A. Karpino
- Pol A. Dasil'Va Dzhardin
- Brjus A. Lefker
- Dzhon A. Rehgehn
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RU2172742C2 |
