FIELD: chemistry of peptides. SUBSTANCE: product: peptides of the general formula: Trp-X-Gly-Gly-Asp-R where X - residue of hydroxyl-containing amino acid of L- or D-configuration; R - peptide Ala-Ser-Gly-Glu or Ala-Ser-Gly, or Ala-Ser or Ala, and their pharmaceutically acceptable salts also. Synthesis of peptides is carried out by the successive peptide chain splicing using tert.-butylhydroxycarbonyl scheme of solid-phase peptide synthesis. Synthesis is carried out at automatic regime in peptide synthesizer. Synthesized peptides are used in medicine since they show antistress, anticonvulsant and neuroprotective effect. EFFECT: improved method of synthesis, enhanced effectiveness of peptides. 7 tbl
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Authors
Dates
1998-07-20—Published
1997-01-28—Filed