Patenton — panteon of patents

(19)

RU

(11)

2 112 528

(13)

C1

(51)

IPC

(21) (22)

Application

94043698/14, 1994-12-23

(22)

Actual filing date

1994-12-23

(45)

Published

1998-06-10

(72)

Inventor

Sverdlov E.D.Baskova I.P.Zavalova L.L.Luk'Janov S.A.Barsova E.V.Bogdanova E.A.

(73)

Holder

Institut Bioorganicheskoj Khimii Im.M.M.Shemjakina I Ju.A.Ovchinnikova Ran

METHOD OF PREPARING ENZYME DESTABILASE SHOWING FIBRINOLYTIC, THROMBOLYTIC, ENDO- AND EXO-GAMMA)-LYS-ISOPEPTIDASE AND AMIDOLYTIC ACTIVITY Russian patent published in 1998 - IPC

Abstract RU 2112528 C1

FIELD: medicine, biochemistry. SUBSTANCE: invention relates to new thrombolytic enzyme destabilase, endo-ε(γ-Glu)-Lys-isopeptidase, showing exo-ε(γ-Glu)-Lys-isopeptidase and amidolytic activity. Enzyme is obtained from leech of family Hirudinidae. Leech extract is subjected for affinity chromatography, purified additionally by ion-exchange chromatography, desalted by gel-filtration and protein of molecular mass 126 000 ± 300 Da is collected. Partial amino acid sequence of this enzyme is identified. Product can be used in medicine for thrombosis therapy and in experimental medicine. EFFECT: new enzyme indicated above, improved method of preparing. 2 dwg

Similar patents RU2112528C1

Title Year Author Number
FIBRINE-ISOPEPTIDASE 1991
  • Sverdlov Evgenij Davidovich
  • Zavalova Ljudmila L'Vovna
  • Kuzina Elena Vital'Evna
 RU2049819C1
PEPTIDES SHOWING ANTISTRESS, ANTICONVULSANT AND NEUROPROTECTIVE EFFECT 1997
  • Mikhaleva I.I.
  • Prudchenko I.A.
  • Mendzheritskij A.M.
  • Vilkov G.A.
 RU2115660C1
GLYCOPEPTIDE FULLERENE DERIVATIVE SHOWING ADJUVANT ACTIVITY 1997
  • Zhmak M.N.
  • Vol'Pina O.M.
  • Kuprijanova M.A.
  • Andronova T.M.
  • Makarov E.A.
  • Romanova V.S.
  • Parnes Z.N.
  • Vol'Pin M.E.
  • Ivanov V.T.
 RU2124022C1
METHOD OF ISOLATION AND PURIFICATION OF INSULIN OR ITS BIOTECHNOLOGICAL PRECURSORS 1994
  • Mal'Tsev K.V.
  • Miroshnikov A.I.
  • Vul'Fson A.N.
  • Gavrjuchenkova L.P.
  • Gromova O.A.
 RU2081122C1
RECOMBINANT PLASMID DNA pET15/N-Dest+ AND METHOD FOR THE PREPARATION, THE STRAIN OF ESCHERICHIA COLI BL21(DE3)GOLD, TRANSFORMED BY RECOMBINANT DNA pET15/N-Dest+, AND A METHOD OF ITS RECEPTION, A METHOD FOR OBTAINING RECOMBINANT BIFUNCTION ENZYME - DESTABILASE OF MEDICAL LEECH 2015
  • Lazarev Vasilij Nikolaevich
  • Manuvera Valentin Aleksandrovich
  • Kurdyumov Aleksej Sergeevich
  • Akhaev Dmitrij Nikolaevich
  • Baskova Izolda Parfirevna
 RU2658429C2
METHOD OF PREPARING MODIFIED MACROPOROUS SILICA FOR CHROMATOGRAPHY OF BIOPOLYMERS 1988
  • Saburov V.V.
  • Zubov V.P.
  • Turkin S.I.
  • Kiselev E.M.
  • Dimitriev K.N.
  • Tsar'Kova M.S.
 RU2080905C1
METHOD OF SYNTHESIS OF SECONDARY AMINES 1998
  • Kubrakova I.V.
  • Formanovskij A.A.
  • Mikhura I.V.
 RU2148055C1
PROCESS FOR PREPARING HUMAN PROINSULIN 1991
  • Mal'Tsev K.V.
  • Vul'Fson A.N.
  • Ivanov V.T.
 RU2045535C1
METHOD OF SYNTHESIS OF δ-SLEEP PEPTIDE 1995
  • Bezrukov M.V.
  • Panchenko A.E.
  • Prudchenko I.A.
  • Mikhaleva I.I.
  • Ivanov V.T.
 RU2111972C1
PEPTIDES SHOWING REGENERATIVE-REPARATIVE ACTION 1994
  • Onoprienko L.V.
  • Mikhaleva I.I.
  • Vojtenkov B.O.
  • Ivanov V.T.
  • Okulov V.B.
 RU2065445C1

RU 2 112 528 C1

Authors

Sverdlov E.D.

Baskova I.P.

Zavalova L.L.

Luk'Janov S.A.

Barsova E.V.

Bogdanova E.A.

Dates

1998-06-10—Published

1994-12-23—Filed

read Similar patents