FIELD: organic chemistry and technology. SUBSTANCE: products: derivatives of pyridone biphenyl of the formula (I) 
and their salts where R1 is COOH, C1-C8--alkoxycarbonyl; R2 is C1-C8--alkyl, group -CH2-O-R5 where R5 is C1-C10--alkyl; R3 is hydrogen; R4 is hydrogen, halogen, C1-C6--alkyl, hydroxy-group, C1-C8--alkoxy-group, CF3, CF3O. Reagent 1: compound of the formula (II) 
where R1 and R2 have above indicated values. Reagent 2: compound of the formula (III) 
where R3 and R4 have above indicated values; R6 is triphenylmethyltetrazolyl; E is chlorine or bromine. Reaction conditions: in medium of inert solvent, in the presence of base and catalyst if necessary. Compounds of the formula (I) show specific antagonistic effect with respect to angiotensin-II, they inhibit vasoconstrictive and aldosterone secretion stimulating effects of angiotensin-II and proliferation of smooth muscle cells. Synthesized compounds are used in medicine for treatment of patients with hypertension and atherosclerosis. EFFECT: improved method of synthesis, enhanced effectiveness of compounds.
| Title | Year | Author | Number |
|---|---|---|---|
| DERIVATIVES OF CYCLOALKANOINDOLE AND AZAINDOLE, MIXTURE OF THEIR ISOMERS OR SEPARATE ISOMERS AND THEIR PHARMACEUTICALLY ACCEPTABLE SALTS, DERIVATIVES OF CARBOXYLIC ACID AS PARENT COMPOUNDS AND PHARMACEUTICAL COMPOSITION INHIBITING RELEASE OF LIPOPROTEINS ASSOCIATED WITH APOLIPOPROTEIN B-100 | 1995 |
|
RU2157803C2 |
| DERIVATIVES OF HETEROCYCLE-SUBSTITUTED PHENYLCYCLOHEXANECARBOXYLIC ACID, MIXTURE OR THEIR ISOMERS OR INDIVIDUAL ISOMERS AND THEIR SALTS | 1994 |
|
RU2119480C1 |
| DERIVATIVES OF PYRIDOBENZOXADIAZINE CARBOXYLIC ACID, MIXTURE OF THEIR ISOMERS OR SEPARATE ISOMERS, THEIR PHARMACEUTICALLY USED HYDRATES AND SALTS AND PHARMACEUTICAL COMPOSITION SHOWING ANTIBACTERIAL ACTIVITY ON THEREOF | 1995 |
|
RU2138504C1 |
| DERIVATIVES OF CYCLOPENTANE- OR CYCLOPENTENE--β--AMINO ACIDS AND THEIR SALTS, A COMPOSITION EXHIBITING ACTIVITY WITH RESPECT TO THE STRAINS STREPTOCOCCUS AUREUS, CANDIDA AND TRICHOPHYTON | 1993 |
|
RU2126379C1 |
| CYCLOHEXANE IMIDAZOLYL SUBSTITUTED DERIVATIVES OR SALTS THEREOF | 1993 |
|
RU2110514C1 |
| DERIVATIVES OF HETEROCYCLE-SUBSTITUTED PHENYLCYCLOHEXANE CARBOXYLIC ACID, MIXTURE OF THEIR ISOMERS OR SEPARATE ISOMERS AND THEIR SALTS | 1994 |
|
RU2125990C1 |
| QUINOLONE-AND NAPHTHIRIDONECARBOXYLIC ACID DERIVATIVES IN ADMIXTURE WITH ISOMERS OR INDIVIDUAL ISOMERS, HYDRATES AND SALTS THEREOF, AND PHARMACEUTICAL COMPOSITION | 1993 |
|
RU2105770C1 |
| DERIVATIVES OF PYRIDOBENZOXADIAZINE, MIXTURE OF THEIR ISOMERS OR SEPARATE ISOMERS, THEIR HYDRATES AND SALTS | 1994 |
|
RU2131430C1 |
| DERIVATIVES OF BENZOFURANYLALKANE CARBOXYLIC ACID OR A MIXTURE OF THEIR ISOMERS, OR SEPARATE ISOMERS, OR THEIR SALTS | 1994 |
|
RU2125564C1 |
| ARYLIDENE-OR ARYLALKYL-1-AZACYCLOALKANE DERIVATIVES, MIXTURES OF ISOMERS THEREOF OF ISOMERS THEREOF OF INDIVIDUAL ISOMERS OR SALTS | 1993 |
|
RU2126400C1 |
