FIELD: organic synthesis. SUBSTANCE: invention provides compounds having general formula (1) where A is unsubstituted phenyl, unbranched and branched C1-C8-alkyl or C3-C8-cycloalkyl; B and D form together groups , , or wherein R2 and R3, the same or different, are unbranched or branched C1-C8-alkyl or halogen; T is tetrazolyl, unsubstituted or substituted trifluoromethyl, or radicals with general formulas -CO2R4, -CO-NR5SO2R6 and -CONR7CHR8R9 wherein R4 is hydrogen, unbranched or branched C1-C8-alkyl; R5 = R7 are hydrogen, R6 phenyl substituted by unbranched C1-C6-alkyl, R8 is phenyl optionally monosubstituted by halogen, R9 is hydroxymethyl, aminocarbonyl, or pyridyl. Provided are also mixtures of isomers of these compounds and their salts showing biological activity, in particular, antagonistic activity relative to angiotensin II. EFFECT: : new efficient drugs prepared. 2 cl, 7 tbl, 46 ex
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Authors
Dates
1998-09-27—Published
1994-02-14—Filed