RING-SUBSTITUTED PHENYLOXAZOLIDINONES WITH HETEROAROMATIC RINGS AS ANTIBACTERIAL AGENTS Russian patent published in 2000 - IPC

FIELD: organic chemistry, heterocyclic compounds. SUBSTANCE: invention describes the novel compounds, phenyloxazolidinones substituted with heteroaromatic rings in ring of the formula (Ia) or its pharmaceutically acceptable salts where: Q means heteroaromatic 5-membered ring bound with aromatic ring (1) in nitrogen atom of the structural formulas: (Ia), (I) , (II) , (III) , (IV) , (V) , (VI) , (VII) , (VIII) or (IX) or in other variant Q can mean heteroaromatic 5-membered ring condensed with benzene and bound with aromatic ring (1) of the structural formula (X) ; R¹ means independently H, F or Cl; R² means independently C₁-C₈-alkyl optionally substituted with one or more atoms of F or Cl; R³ each is taken independently among of: (a) H; (b) OR⁴; (c) SR⁴; (d) NHSO₂R⁴; (e) CO₂R⁴; (f) COR⁴; (g) saturated or unsaturated C₁-C₈-alkyl that can be direct or branched and optionally substituted with one or more substituent taken among of (e), (j) -C(R⁵)=NR⁶ where R⁵ means C₁-C₆-alkyl and R⁶ means OH orOC₁-C₆ OC₁-C₆-alkyl; R⁴ means: (a) H; (b) C₁-C₆-direct or branched alkyl chain. These compounds are useful antibacterial agents showing activity against human and animal pathogens including gram-positive aerobic bacteria, for example, multiple-resistant staphylococci, streptococci and enterococci and also anaerobic microorganisms, for example, Bacteroides spp. , Clostridium spp. and acid-fast microorganisms, for example, Mycobacterium tuberculosis, Mycobacterium avium and Mycobacterium spp. EFFECT: new compounds indicated above, valuable antibacterial properties. 11 cl, 8 dwg, 1 tbl