DERIVATIVES OF TAXANE-III, METHODS OF THEIR SYNTHESIS AND A PHARMACEUTICAL COMPOSITION Russian patent published in 1998 - IPC

FIELD: organic chemistry. SUBSTANCE: invention relates to new derivatives of taxane-III of the formula (I) where R₁= is H; R₁₄= is H, C₂-C₉-alkanoyl nonsubstituted with halogen atom, or R₁ and R₁₄ taken together are carbonyl or lower alkylidene; R₇= R₁₀ is H, tri(lower alkyl)silyl or free C₂-C₉-alkalnoyl or that mono-, di- or tri-substituted with halogen atom; R₁₃ is H, group -COCHOHCH-(C₆H₅)--NHCO-C₆H₅ or -COCHOHCH-(C₆H₅)--NHCOOC-(CH₃)₃; Ac is acetyl. These compounds show antitumor activity. Invention relates to also methods of synthesis of compounds of the formula (I) where R₁= R₇= R₁₀= R₁₃= R₁₄ - H from plant Taxus Walliehiana above ground parts and methods of synthesis of compounds of the formula (I) with different values of radicals R₁, R₇, R₁₀, R₁₃ and R₁₄, and pharmaceutical composition based on taxane derivatives of the formula (I). EFFECT: improved method of synthesis.