DERIVATIVES OF β--AMINO--α--HYDROXYCARBOXYLIC ACIDS OR THEIR PHARMACEUTICALLY ACCEPTABLE SALTS OR ESTERS, PHARMACEUTICAL COMPOSITION Russian patent published in 1998 - IPC

FIELD: organic chemistry. SUBSTANCE: invention relates to derivatives of β--amino--α--hydroxycarboxylic acids of the general formula (I): β- where -α- being A is -CO, R₁-NR₂-CH(R₃)CONHCHR₄CHOHCOR₅,; Z is O; X = 0 or 1; R is R_I=R(Z)_xA,-alkyl that can be optionally substituted with phenyl or phenoxy-group, carbocyclic aryl-group containing up to 10 carbon atoms, 5-6-membered heterocyclic group containing from 1 to 4 heteroatoms taken from nitrogen, oxygen, sulfur being heterocyclic group can be fused with benzene nucleus and can be free or substituted with at least one substituent taken from hydroxy-, -SO₂,-alkyl, C₁-C₆-alkoxy, (C₁-C₆)-alkoxyphenyl, (C₁-C₆) or R is (C₁-C₆); H₂NCH₂COO-, CH₃COO- and NR^aR^b, are taken independently from hydrogen and R^a-aryl, R^b-substituted; (C₆-C₁₄) is H; (C₁-C₃) is hydrogen, R₂-alkyl that can be substituted with hydroxyl, carbamoyl, cyano-group, carboxy-group, mono-R₃- or di-(C₁-C₆)-alkylcarbamoyl; (C₁-C₆) is (C₁-C₆)-alkyl substituted with phenyl or cyclohexyl; R₄ is 5-10-membered heterocyclic system or their pharmaceutically acceptable salts, or esters and pharmaceutical composition based on thereof. The synthesized compounds are used in medicine, for treatment of patients with retroviral infections, in part, with AIDS. EFFECT: improved method of synthesis, enhanced effectiveness of compounds. 19 cl, 1 tbl