METHOD OF ESTIMATION OF ADRENOREACTIVITY OF PREGNANT WOMEN RED CELLS BY ALTERNATION OF RED CELLS PRECIPITATION RATE AT THE BACKGROUND OF BLOCKADE OF THEIR β--ADRENORECEPTORS (ASSAY OF β--ADRENODEPENDENT RATE OF RED CELLS PRECIPITATION) Russian patent published in 1998 - IPC

FIELD: medicine, laboratory diagnosis. SUBSTANCE: method involves determination of erythrocyte physical-chemical properties by effect of β--adrenoblocking agent propranolol (obsidan, anaprilin) that is added to analyzed citrate blood in vitro. Alternations of erythrocytes physical-chemical properties are determined by decrease of erythrocyte precipitation rate which is assayed by conventional procedure under condition that the parent value is above 10 mm/h. Assay is carried out in the presence of β--adrenoblocking agent obsidan taken at the range of concentrations 1 x 10^-5, 1 x 10^-6-1 x 10^-13 g/ml. Adrenoreactivity is estimated to be moderate (normal) if β--adrenodependent erythrocyte precipitation rate value is 60-80% of control, at 80% - as a decreased one and at 60% - as an increased one. Method ensures to diagnose gestosis, abortion and its pathogenetic treatment. EFFECT: improved method of estimation and diagnosis. 3 ex