FIELD: organic chemistry, pharmacy. SUBSTANCE: invention describes selective inhibitors of thrombin of the following formula (I) R1,R6,R7 where values 
, X are given in p. 1 of the invention claim. These compounds can be used orally also. Invention describes also a pharmaceutical composition based on compounds of the formula (II) used for inhibition of thrombin activity. EFFECT: valuable pharmacological properties of compounds. 4 cl, 7 tbl, 58 ex
| Title | Year | Author | Number |
|---|---|---|---|
| METHOD OF SYNTHESIS OF DERIVATIVES OF 2-AMINOTHIAZOLE CARBOXAMIDE | 1999 |
|
RU2193034C2 |
| DERIVATIVES OF IMIDAZOLE ELICITING INHIBITORY ACTIVITY WITH RESPECT TO FARNESYLTRANSFERASE, METHOD OF THEIR SYNTHESIS, INTERMEDIATE COMPOUNDS, PHARMACEUTICAL COMPOSITION | 1998 |
|
RU2179975C1 |
| GLUCOKINASE ACTIVATORS AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM AS ACTIVE INGREDIENT | 2008 |
|
RU2450001C2 |
| NOVEL METHOD OF PRODUCING IOPROMIDE | 2009 |
|
RU2451667C1 |
| QUINAZOLINE DERIVATIVES FOR SLOWING DOWN GROWTH OF CANCER CELLS AND METHOD OF OBTAINING THEM | 2005 |
|
RU2362773C2 |
| SPHINGOSINE-1-PHOSPHATE RECEPTOR AGONIST, METHOD OF ITS PRODUCTION AND PHARMACEUTICAL COMPOSITION CONTAINING IT AS AN ACTIVE INGREDIENT | 2020 |
|
RU2798605C1 |
| DERIVATIVES OF QUINOLINE- OR NAPHTHYRIDINE CARBOXYLIC ACID AND METHODS OF THEIR SYNTHESIS | 1995 |
|
RU2120940C1 |
| USE OF TALIPORFIN OR ITS DERIVATIVES IN TREATMENT OF HEART DISEASES, AND ALSO THEIR DERIVATION | 2001 |
|
RU2350326C2 |
| 2-CYANOPYRIMIDINE-4-YL CARBAMATE, OR A UREA DERIVATIVE, OR ITS SALT AND A PHARMACEUTICAL COMPOSITION CONTAINING THEM | 2019 |
|
RU2788740C2 |
| NEW ACYCLIC NUCLEOSIDE PHOSPHONATE DERIVATIVES, THEIR SALTS AND METHOD FOR PREPARING THESE COMPOUNDS | 2002 |
|
RU2266294C2 |
