N-[[1-[4-(FLUOROPHENOXY)BUTYL]-4-PIPERIDINYL]-N-METHYLAMINO]-2-BENZTHIAZOLES OR THEIR PHARMACEUTICALLY ACCEPTABLE ACID SALTS, A METHOD OF SYNTHESIS, AN ANTIARRHYTHMIC COMPOSITION OF THE THIRD-CLASS AND A METHOD OF ITS PREPARING Russian patent published in 1998 - IPC

Abstract RU 2122546 C1

FIELD: organic chemistry. SUBSTANCE: invention relates to new derivatives of 2-benzthiazole of the formula (I) where one of substituents R1 and R2 is a hydroxy-group and other means hydrogen, or their pharmaceutically acceptable acid salts. Compound (I) is synthesized by N-alkylation of an intermediate compound (II) where R1 and R2 as indicated above with reagent of the formula (III) where W is a split off group. Compounds of the formula (I) can be used as an antiarrhythmic agents of the third-class. EFFECT: improved method of synthesis, new compounds indicated above. 8 cl, 1 tbl, 13 ex

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RU 2 122 546 C1

Authors

Jozef Jan Piter Khejkants

Marsel' Jan Marija Borgers

Doris Vil'Khel'M

Dates

1998-11-27Published

1994-06-06Filed