DERIVATIVES OF PYRROLEQUINOLINONE, METHOD OF THEIR SYNTHESIS, INTERMEDIATE COMPOUNDS FOR THEIR SYNTHESIS, PHARMACEUTICAL COMPOSITION AND METHOD OF ITS PREPARING Russian patent published in 1999 - IPC

FIELD: organic chemistry, pharmacy. SUBSTANCE: invention relates to derivatives of pyrrolequinolinone of the formula (I) where L - radical of the formula -O-Alk-(NH)_p-C(=O)-R₁ where Alk - C_1-6-alkanediyl; p = 0 or 1; R₁ - hydroxy-, alkoxy-group or -NR²R³; R² - H or alkyl; R³ is C_3-7-cycloalkyl or piperidinyl possibly substituted with alkyl, phenylmethyl or C_3-7-cycloalkylmethyl; R² and R³ can form piperazinyl- or piperidinyl-group, or their pharmaceutically acceptable additive salts or their stereochemically isomeric forms that are strong inhibitors of phosphodiesterase of type III (cardiotonically-sensitive PDE III). EFFECT: improved method of synthesis, strong inhibitors of enzyme PDE III. 10 cl, 2 tbl, 16 ex