4-PHENYLPIPERAZINE AND 4-PHENYLPIPERIDINE OXIDES, COMPOSITION BASED ON THEREOF AND A METHOD OF INHIBITION OF DOPHAMINE-2 RECEPTORS Russian patent published in 1998 - IPC

FIELD: organic chemistry, pharmacology. SUBSTANCE: invention relates to oxides of 4-phenylpiperazines and 4-phenylpiperidines of the general formula (I) where R¹ is C_1-8-alkoxy; R² is hydrogen or methyl; A is N, CH or N⁺-O^-; B means N or N⁺-O^- at condition that when A means N or CH then B must be N, or their pharmaceutically acceptable salts. The synthesized compounds show significant activity in mammals and neuroleptic and antipsychotic effect in human. EFFECT: improved method of synthesis, enhanced effectiveness of compounds synthesized. 20 cl, 1 tbl, 3 ex, 7 dwg