NIPECOTINIC ACID DERIVATIVES AS AGENTS THAT PREVENT BLOOD CLOT FORMATION Russian patent published in 1999 - IPC

FIELD: medicine. SUBSTANCE: compounds based on fibrinogen of formula: wherein X¹ and X² are H₂ or O; Y is (CH₂)_m, CH(NHCOR³)-(CH₂)_m,, CH(NH₂(CH₂)_m; A is NHR¹,C(:NH)NH₂ or pyperidine or pyrrolidine; Z is (CH₂)_n,CH(CO₂R⁴)(CH₂)_n; R¹ is hydrogen alkyl or CH(NH)NH₂;; R² is hydrogen or alkyl; R³ is alkoxy or alkyl; R⁴ is alkyl or arylalkyl; R⁶ is hydrogen, alkyl or arylalkyl; m is integer of 0-3; n is integer of 0-2, are thrombocyte aggregation inhibitors useful for treatment of blood coagulation disorders. EFFECT: improved properties of the title compounds. 8 cl, 19 ex, 4 tbl