GLYCEROL DERIVATIVES, AN AGENT FOR DELIVERY OF PHYSIOLOGICALLY ACTIVE SUBSTANCE, PHARMACEUTICAL COMPOSITION Russian patent published in 1998 - IPC

FIELD: pharmacy. SUBSTANCE: invention relates to construction of lipid agent which is equivalent to cationic liposome but less toxic and containing lipid or its analog as a component of this agent. Invention relates to compounds of the general formula (I) where R¹ and R² are distinct and each means a group -O-Y or a group -A-(CH₂)_n-E where n is a whole number from 2 to 4; E means pyrrolidine-, piperidine- or morpholine-group or others, or E means a group where R³ and R⁴ are similar or distinct and each means hydrogen atom, lower-(C₁-C₄)-alkyl, hydroxy-lower-(C₁-C₄)- -alkyl; A means groups of formulas: where R and Y are similar and each means oleyl or oleoyl or palmitoyl at condition that when n = 1 then A can not be a group and . Invention relates to also an agent for delivery of physiologically active substance containing phospholipid and modifying component, and a pharmaceutical composition containing an agent for delivery of physiologically active substance, physiologically active substance and an inert diluting agent. EFFECT: improved properties of composition. 12 cl, 2 tbl, 50 ex