FIELD: organic chemistry, pharmacy. SUBSTANCE: invention relates to chemistry of heterocyclic compounds showing antagonism with respect to 5-HT2-receptors and activity inhibiting reuptake of 5-HT. Invention relates to derivative of morpholine of the formula (I) 
where R1 and R3 are similar or distinct and each means hydrogen atom or lower alkyl-group; R2 is halogen atom and dotted line means optionally double bond, or its pharmaceutically acceptable salts, and pharmaceutical composition based on thereof. These compounds can be used for synthesis of antidepressive and sedative drugs. EFFECT: improved method of synthesis. 7 cl, 4 tbl
| Title | Year | Author | Number |
|---|---|---|---|
| 1,2,3,4-TETRAHYDROQUINOXALIDINEDIONE DERIVATIVES AND PHARMACEUTICAL COMPOSITION | 1995 |
|
RU2149873C1 |
| THIOPHENE DERIVATIVE AND PHARMACEUTICAL COMPOSITION BASED ON THEREOF | 1997 |
|
RU2172737C2 |
| 1,2,4-TRIAZOLONE DERIVATIVE | 2011 |
|
RU2566754C2 |
| DERIVATIVE OF TRIAZASPIRO[5,5]UNDECANE AND PHARMACEUTICAL COMPOSITION COMPRISING ITS AS ACTIVE COMPONENT | 2002 |
|
RU2269528C2 |
| CONDENSED BENZAZEPINE DERIVATIVE, AN INTERMEDIATE COMPOUND FOR ITS SYNTHESIS, A PHARMACEUTICAL COMPOSITION | 1994 |
|
RU2129123C1 |
| AMIDINONAPHTYL DERIVATIVES AND PHARMACEUTICAL COMPOSITION | 1995 |
|
RU2154633C2 |
| QUINOLONE COMPOUND AND PHARMACEUTICAL COMPOSITION | 2009 |
|
RU2544530C2 |
| DERIVATIVE OF 4,4-DIFLUORO-1,2,3,4-TETRAHYDRO-5H-BENZAZEPINE, ITS SALT AND PHARMACEUTICAL COMPOSITION COMPRISING THEREOF | 2002 |
|
RU2268882C1 |
| DERIVATIVES OF AZOLE, PHARMACEUTICAL COMPOSITION BASED ON THEREOF, INTERMEDIATE COMPOUNDS | 1995 |
|
RU2161612C2 |
| NEW 2-HETEROARYL-SUBSTITUTE BENZIMIDAZOLE DERIVATIVE | 2004 |
|
RU2329261C2 |
