DERIVATIVE OF 4,4-DIFLUORO-1,2,3,4-TETRAHYDRO-5H-BENZAZEPINE, ITS SALT AND PHARMACEUTICAL COMPOSITION COMPRISING THEREOF Russian patent published in 2006 - IPC C07D223/16 C07D401/06 C07D401/12 C07D401/14 C07D403/06 C07D403/10 C07D403/12 C07D403/14 C07D405/14 C07D409/14 C07D417/14 A61K31/55 A61P7/12 A61P13/00 

FIELD: organic chemistry, medicine, pharmacy.

SUBSTANCE: invention relates to novel biologically active compounds that act as agonists of arginine-vasopressin V₂-receptors. Invention describes a derivative of 4,4-difluoro-1,2,3,4-tetrahydro-5H-benzazepine represented by the general formula (I): or its pharmaceutically acceptable salt wherein symbols have the following values: R¹ represents -OH, -O-lower alkyl or optionally substituted amino-group; R² represents lower alkyl that can be substituted with one or more halogen atoms, or halogen atom; among R³ and R⁴ one of them represents -H, lower alkyl or halogen atom, and another represents optionally substituted nonaromatic cyclic amino-group, or optionally substituted aromatic cyclic amino-group; R⁵ represents -H, lower alkyl or halogen atom. Also, invention describes a pharmaceutical composition representing agonist of arginine-vasopressin V₂-receptors. Invention provides preparing new compounds possessing with useful biological properties.

EFFECT: valuable medicinal properties of compound and composition.

9 cl, 18 tbl, 13 ex