METHOD OF TREATING ENDOTOXIN SHOCK Russian patent published in 1998 - IPC

Abstract RU 2123861 C1

FIELD: intestinal diseases. SUBSTANCE: treatment is effected by introducing therapeutically active substance: anti-adhesive antibody or its fragment. Antibody is selected from the group including anti-CD18 and anti-ICAM-1 antibodies, the former being preferably monoclonal R 15.7 antibody and the latter monoclonal R 6.5 antibody. Antibody is introduced intravenously in amounts from 0.1 to 10 mg/kg. Above-mentioned fragment may be Fab or F(ab)2 fragment of anti-adhesive antibody. EFFECT: simplified procedure and enhanced its efficiency. 6 cl, 1 dwg, 2 ex

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RU 2 123 861 C1

Authors

Lindsej Gordon Letts

Stiven M.Uehldon

Dzhenus Dzh.Possantsa

Dates

1998-12-27Published

1991-08-30Filed