FIELD: organic chemistry, pharmacy. SUBSTANCE: invention relates to compounds of the formula (I) 
and (II) 
where R means hydrogen; R1 means alkyl, amino-group or substituted amino-group; R2 means optionally substituted phenyl; R3 means hydrogen, halogen or optionally substituted alkyl; R4 means hydrogen, optionally substituted alkyl, aryl or aralkyl. Synthesized compounds show analgetic, antiinflammatory activity and capability to inhibit leukotriene production, bone resorption and selective inhibition of COX-2 activity. Invention proposes also a pharmaceutical composition based on compounds said. EFFECT: improved method of synthesis, enhanced effectiveness of compounds. 17 cl, 130 ex, 13 tbl
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