FIELD: agriculture. SUBSTANCE: present invention describes milbemycin 13- substituted derivatives of formula I 
wherein R1 is methyl, ethyl, isopropyl or sec-butyl; R2 is hydrogen and alkyl; X is (α-hydroxyimino-or α-alkoxyimino substituted) aryl-methyl or (α-hydroxyimino-or α- alkoxyimino substituted) heterocyclylmethyl, N- substituted aminophenyl or N-substituted aminophenoxy group; m is 0 or 1, and n is 0 or 1 both suitable as antihelmintic, acaricidal and insecticidal agents for agriculture and horticulture. EFFECT: improved properties of the acaricidal and insecticidal composition. 24 cl, 7 dwg , 12 tbl
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