DERIVATIVES OF DIARYLALKANES CONTAINING ALICYCLIC GROUP AND ELICITING ANTAGONISM WITH RESPECT TO SEROTONIN-2-RECEPTORS AND/OR INHIBITORY ACTIVITY WITH RESPECT TO SQUALENE SYNTHASE, COMPOSITION FOR TREATMENT AND PROPHYLAXIS OF CARDIOVASCULAR DISEASES Russian patent published in 1999 - IPC

Abstract RU 2139277 C1

FIELD: organic chemistry, pharmacy. SUBSTANCE: invention relates to derivatives of diarylalkanes of the formula (I) where R1 - unsaturated heterocyclic group with 5 ring atoms one of that is nitrogen and possibly substituted by one of carbon atom with OH-group or C1-20-alkanoyl- -hydroxy-group and possibly substituted by nitrogen atom with C1-6-alkyl; R2a,R2b,R2c - H, methyl, methoxy-group, F, Cl, Br; R3a,R3b,R3c,R3d - H, C1-6-alkoxy-group or halogen atom, and their pharmaceutically acceptable salts and esters. Compounds of the formula (I) are antagonists of serotonin-2-receptors and show capability to inhibit squalene synthase activity. EFFECT: valuable biochemical and pharmacological properties of compounds. 18 cl, 4 tbl, 20 ex

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RU 2 139 277 C1

Authors

Koiti Fudzimoto

Naoki Tanaka

Fumitosi Asaj

Taketosi Ogava

Tejitiro Koga

Tatsuo Tanimoto

Esio Tsudzita

Khirojuki Kojke

Dates

1999-10-10Published

1997-02-14Filed