FIELD: organic chemistry, pharmacy. SUBSTANCE: invention relates to derivatives of diarylalkanes of the formula (I) where R1 - unsaturated heterocyclic group with 5 ring atoms one of that is nitrogen and possibly substituted by one of carbon atom with OH-group or C1-20-alkanoyl- -hydroxy-group and possibly substituted by nitrogen atom with C1-6-alkyl; R2a,R2b,R2c - H, methyl, methoxy-group, F, Cl, Br; R3a,R3b,R3c,R3d - H, C1-6-alkoxy-group or halogen atom, and their pharmaceutically acceptable salts and esters. Compounds of the formula (I) are antagonists of serotonin-2-receptors and show capability to inhibit squalene synthase activity. EFFECT: valuable biochemical and pharmacological properties of compounds. 18 cl, 4 tbl, 20 ex
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Authors
Dates
1999-10-10—Published
1997-02-14—Filed