OXIME DERIVATIVES AND A PHARMACEUTICAL COMPOSITION BASED ON THEREOF Russian patent published in 1998 - IPC

FIELD: organic chemistry, pharmacy. SUBSTANCE: invention relates to derivatives of oxime of the formula (I) where R¹ is H, C_1-6-alkyl; R² is C_2-6-alkylene; X is an nonsubstituted C_6-10-aryl or that substituted with one substitute taken from a group involving C_1-6-alkyl, OH, acylhydroxy-group, C_1-4-alkoxy-group, halogen atoms, phenyl, phenylthio-group, phenylsulfonyl-group, phenylsulfonylamino-groups, pyridylsulfonyl-groups, imidazolyl- and pyridyl-groups or heteroaromatic group: pyridyl, quinolyl and imidazolyl; y is O, S or -H; Z means a group of the formula (Za) , (Zb) , (Zc) or (Zd) . Compounds (I) can be used for treatment and prophylaxis of patients with hyperlipidemia, hyperglycaemia and obesity. EFFECT: improved method of synthesis, enhanced effectiveness of compounds. 27 cl, 27 tbl, 57 ex