DERIVATIVES OF AMINOMETHYLPYRROLIDINE WITH AROMATIC SUBSTITUTES Russian patent published in 2005 - IPC

FIELD: organic chemistry, medicine, pharmacy.

SUBSTANCE: invention relates to new derivatives of aminomethylpyrrolidine of the formula (I) , their salts or hydrates wherein R¹ represents aryl with from 6 to 10 carbon atoms or heteroaryl wherein heteroaryl is a five-membered ring or a six-membered ring and comprises from 1 to 2 heteroatoms taken among nitrogen, oxygen and sulfur atom; aryl and heteroaryl can comprise one or more substitutes taken among the group consisting of halogen atom or (C₁-C₆)-alkoxyl; each radical among R², R³, R⁴, R⁵, R⁶, R⁷ and R⁸ represents hydrogen atom (H) independently; Q represents incomplete structure representing by the following formula: wherein R⁹ means (C₃-C₆)-cyclic alkyl that can be substituted with halogen atom; R¹⁰ means hydrogen atom (H); R¹¹ means hydrogen atom (H), NH₂; X¹ means halogen atom; A¹ represents incomplete structure representing by the formula (II): wherein X² means hydrogen atom (H), halogen atom, halogenmethoxyl group, (C₁-C₆)-alkyl or (C₁-C₆)-alkoxyl group; X² and above indicated R⁹ can be combined to form the ring structure and inclusion part of the main skeleton and such formed ring comprises oxygen, nitrogen or sulfur atom as a component atom of the ring and the ring can comprise (C₁-C₆)-alkyl as a substitute; Y means hydrogen atom (H). Compounds of the formula (I) elicit an antibacterial effect and can be used for preparing a therapeutic agent.

EFFECT: valuable medicinal properties of compounds.

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