FIELD: organic chemistry and chemical technology. SUBSTANCE: invention relates to compounds of the formula (I): 
where A is carbon-nitrogen bond or unbranched C1-C4-alkylene group; X is nitromethylene group, cyanomethylene group substituted with cyano-group, aminocarbonyl or C1-C3-alkoxycarbonyl or a group of the formula =N-R7 where R7 is cyano-group, C1-C3-alkanesulfonyl, phenylsulfonyl, aminosulfonyl, aminocarbonyl or phenylcarbonyl; Y is C1-C3-alkoxy-group, phenoxy- or group R8NR9 where R8 is hydrogen, C1-C8-alkyl that at 2, 3 or 4 position can be substituted with hydroxy-group, C1-C3-dialkylamino-group, substituted C1-C4-alkyl group, that can be substituted additionally with hydroxyl-group at 2, 3 or 4 position and others; R1 is hydrogen, C1-C3-alkyl; R9 is hydrogen, C1-C3-alkyl; R2 and R3 are hydrogen or form together carbon-carbon bond; Pyr is pyridyl group; R4 is tetrazolyl, aminocarbonyl, C1-C4-dialkylaminocarbonyl and others; R8 is hydrogen, trifluoromethyl, C1-C3-alkyl, C1-C3-alkyl; n = 2, 3, 4, 5. The synthesized derivatives of pyridine, their enantiomers, cis- or trans-isomers and their salts can be used in pharmaceutical composition showing inhibition of platelets aggregation and thromboxane synthesis. EFFECT: improved method of synthesis, enhanced effectiveness of pharmaceutical composition. 5 cl, 1 tbl, 27 ex
| Title | Year | Author | Number |
|---|---|---|---|
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| CYCLIC IMINO-DERIVATIVES, THEIR ISOMER MIXTURES, ENANTIOMERS, DIASTEREOMERS OR PHYSIOLOGICALLY TOLERATED SALTS SHOWING ANTITHROMBOTIC ACTION | 1991 |
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RU2040519C1 |
| BENZIMIDAZOLE DERIVATIVES, THEIR ISOMERS, MIXTURES OF ISOMERS, HYDRATES OR THEIR PHYSIOLOGICALLY BEARABLE SALTS POSSESSING PROPERTIES ANTAGONISTIC TO ANGIOTENZINE | 0 |
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| METHOD OF PRODUCING DERIVATIVES OF PHENYLACETIC ACID OR THEIR SALTS | 0 |
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SU1170969A3 |
