METHOD OF DETERMINATION OF GENETIC RESISTANCE OF PATIENTS TO INFECTION WITH HUMAN IMMUNODEFICIENCY VIRUS OF THE FIRST TYPE (HIV-1) Russian patent published in 1999 - IPC

Abstract RU 2126048 C1

FIELD: medicine, molecular biology, virology. SUBSTANCE: method involves an isolation of DNA from patient, amplification of structural gene of CCR-5 coreceptor followed by polymerase chain reaction run. Then method involves the measurement of obtained amplificated fragments and detection of deletion mutation using primers of the following structure: 5'-GGGTGGCTGTGTTTGCC-3' and 5'-ACCATGACAAGCGGCAGT-3'. EFFECT: accelerated and simplified procedure of resistance assay. 3 cl, 2 dwg, 4 ex

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RU 2 126 048 C1

Authors

Slominskij P.A.

Shadrina M.I.

Limborskaja S.A.

Sverdlov E.D.

Dates

1999-02-10—Published

1997-01-28—Filed